Move graph having new member choice. Within this data, i measured the fresh urinary Na/K ratio and you will BP within the a dozen,890 players (84% from users was basically out of 2017) for two decades. Ultimately, twelve,877 players were analyzed
Tome Area expected players to get their urine products shortly after awakening in the morning. The newest urinary Na/K proportion try measured using a urinary Na/K ratio-measuring device titled HEU-001F (OMRON Health care Co., Ltd., Kyoto, Japan) (Secondary Fig. 1). The latest display immediately info urinary Na/K ratio proportions. A community nursing assistant mentioned the Na/K proportion regarding place urine types of the participants having fun with the machine, registered the significance, and you can provided immediate viewpoints towards members regarding your measured really worth also explanatory topic towards relationships amongst the urinary Na/K ratio and you may BP (Additional Fig. 2). Tome Town performs fitness checkups inside the for every area annually out-of Could possibly get to help you September. Thus, participants have their urinary Na/K proportion mentioned meanwhile in 2017 and you can 2018.
Details about almost every other measurements was extracted from the medical checkup research of Tome City. Both lbs and body top was in fact counted when you look at the health checkup. Bmi try determined while the pounds (kg)/peak dos (m dos ). BP try mentioned double because of the a tuned public fitness nursing assistant. Given that wellness checkup investigation provided with Tome Area merely integrated the reduced BP aspect of the two BP dimensions values, we can simply is this worth within our studies. Blood pressure try defined as systolic BP (SBP) ? 140 mmHg or diastolic BP (DBP) ? 90 mmHg and you will/or even the use of antihypertensive treatment. Information regarding alcoholic drinks intake is actually gotten by a survey. We computed the liquor intake weekly as follows: we multiplied the newest frequency away from alcohol consumption (daily = eight, either = step 3.5, without chronic ingesting = 0) and you can number of alcohol consumed in one occasion (0–1 drink = 0.5, 1–dos drinks = step one.5, 2–3 drinks = 2.5, and step 3 drinks or higher = 3) and you may divided the product of the seven. One drink from inside the Japan corresponds to 23 grams off ethanol. Studies to your entry to diabetes cures and way to cardio state was indeed worry about-reported regarding the health checkup studies.
With regard to information about the aid of diabetes medication, users chosen you to definitely option regarding the following the solutions: (a) a track record of diabetic issues, (b) below way to all forms of diabetes mellitus, or (c) the https://datingranking.net/tr/dine-app-inceleme/ means to access diabetic issues treatment. Those who replied (c) was in fact categorized as “users away from diabetic issues procedures,” whereas those who answered having (a) or (b) or perhaps not relevant was in fact classified as “other people.” With regard to details about the therapy having heart disease, professionals selected that alternative in the pursuing the solutions: (a) keeps a history of heart problems otherwise (b) being treated for cardiovascular illnesses. Individuals who replied (b) was basically categorized while the “undergoing treatment having cardiovascular disease,” whereas individuals who answered having (a) or perhaps not applicable had been classified as the “someone else.”
To compare the difference between participants who attended health checkups both in 2017 and 2018 and those who attended health checkups only in 2017, we used the t-test for continuous variables and the chi-square test for categorical variables. For each year, we compared the baseline characteristics according to the urinary Na/K ratio level. Moreover, we analyzed the relationship between the urinary Na/K ratio and hypertension adjusted for age, sex, BMI, alcohol intake, use of diabetes medication, and treatment for heart disease. For longitudinal data, we assessed the relationship between change in urinary Na/K ratio and BP change using multiple regression analyses adjusted for age, sex, BMI change, and alcohol intake. In both cross-sectional and longitudinal analyses, we stratified the data according to the use of antihypertensive medication. We further added SBP or DBP in 2017 as a covariate. Furthermore, we analyzed the BP difference according to the urinary Na/K ratio quartile in 2017. To examine the effect of BP due to temperature, we acquired past temperature data from the Japan Meteorological Agency in 2017 and 2018 . We considered P < 0.05 as statistically significant.